Characterizing Apixaban Pharmacokinetics Through Physiologically-Based Pharmacokinetic Modeling: Cri
Apixaban, a factor Xa inhibitor, is a direct oral anticoagulant with a well-balanced elimination; it is eliminated evenly via feces, urine (with no active secretion), and as metabolites after oral administration. The common understanding is that biliary secretion and enterohepatic circulation (EHC) …
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